A curated library of peer-reviewed research on ayahuasca, psilocybin, mescaline, and the integration of plant medicine into clinical and contemplative practice. Maintained by our medical advisory board. Read alongside, not instead of, the work itself.
JAMA Psychiatry · 78(5) · 2021 · doi:10.1001/jamapsychiatry.2020.3285
71% of participants showed clinically significant response at week 4. 54% met criteria for remission from depression. Sustained at follow-up.
Read summary →European Neuropsychopharmacology · 31 · 2020 · doi:10.1016/j.euroneuro.2019.12.110
Symptoms of anxiety, depression, and PTSD in regular ayahuasca users showed sustained reductions across the full 4-year observational window.
Read summary →Journal of Psychopharmacology · 30(12) · 2016 · doi:10.1177/0269881116675513
Single high-dose session produced clinically significant decreases in depression and anxiety in ~80% of patients with life-threatening cancer. Effects persisted at 6-month follow-up.
Read summary →Journal of Psychoactive Drugs · 53(4) · 2021 · doi:10.1080/02791072.2021.1882684
Among 452 respondents, significant improvements reported across depression, anxiety, alcohol use disorder, and drug use disorder following ceremonial mescaline use.
Read summary →Frontiers in Psychiatry · 11 · 2020 · doi:10.3389/fpsyt.2020.00604
Structured integration sessions doubled the durability of effects at 12-month follow-up compared to ceremony-only protocols.
Read summary →Frontiers in Pharmacology · 12 · 2021 · doi:10.3389/fphar.2021.693595
Cohort-based retreats with indigenous-trained facilitators showed significantly higher integration outcomes than clinical settings, particularly in measures of meaning and connectedness.
Read summary →Long-term wellbeing studies in regular ceremonial users · clinical trials of DMT in major depressive disorder · neuroimaging of ayahuasca-induced default mode network changes.
Browse 42 papers →Phase 2/3 clinical trials · single-dose vs. dose-escalating protocols · meta-analyses of psilocybin in treatment-resistant depression and end-of-life anxiety.
Browse 54 papers →Naturalistic survey research · indigenous use studies · comparative pharmacology of mescaline-class compounds · alcohol-use-disorder research.
Browse 18 papers →Post-session integration protocols · group vs. individual integration · cohort-based outcomes · 12-month durability research.
Browse 22 papers →Cardiovascular and SSRI interaction profiles · contraindication research · screening protocol development · adverse event surveillance.
Browse 9 papers →Comparative outcomes across setting types · indigenous facilitation studies · lineage transmission research · the role of ceremonial container.
Browse 3 papers →Each quarter, our medical advisory board selects 6—8 papers worth reading and summarises them in plain language. No spam, no marketing, no newsletter graveyard. Sent to ~12,000 readers since 2021.